Research

Top Down proteomics

Top-down and bottom-up mass spectrometry methods can generate gas phase fragments that are used to identify proteins and proteoforms. Top-down methods provide additional structural information which is otherwise lost using traditional bottom up approaches.

Novel Pharmacological chaperones

Cyclic thiosulfinates are novel class of thiol selective cross-linkers that avoid toxic dead end modifications.

MalDi imaging

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) provides a unique in situ chemical profile that can include drugs, nucleic acids, metabolites, lipids, and proteins.

AMYTROPOHIC LATERAL SCLEROSIS

10 -20% ALS cases are caused by mutations in genes (fALS). We continously work on understanding protein variants associated with ALS to better define ALS etiology.

Collaborators

• 
  Roman Manetsch - Northeastern University
  
• 
  Ke Zhang - Northeastern University
  
• 
  Steven Lopez - Northeastern University
  
• 
  Mary Jo Oondrechen - Northeastern University
  
• 
  Consortium for Top Down Proteomics
  

We are fortunate to establish strong collaborations enabling our influential research

Funding